DIEP seminar by Marilyn Gatica
High-Order Functional Interactions in Health and Therapy: Aging and Transcranial Ultrasound Stimulation
The brain’s interdependencies can be analyzed from structural and functional perspectives. Structural connectivity (SC) typically examines white-matter fibers connecting different regions, while functional connectivity (FC) involves statistical interactions. While SC is inherently pairwise, FC isn’t limited to pairwise relationships; however, most FC analyses still focus on pairwise statistics, often overlooking higher-order interactions.
In this talk, Marilyn will discuss new whole-brain computational models developed using MRI data to explore these interactions in two contexts: healthy aging and TUS. Her findings reveal that non-linear changes in the structural connectome can explain variations in high-order functional interactions between age groups. Additionally, Marilyn will discuss the high-order effects of TUS in targeting different brain areas.
Marilyn Gatica is a Postdoctoral Research Assistant at the Network Science Institute, Northeastern University London. Her research blends data analysis with multivariate information theory, machine learning, and whole-brain modeling. She holds a Bachelor’s degree in Mathematics and a professional degree in Mathematical Engineering from Universidad de Santiago de Chile. Marilyn completed a double doctorate between the University of Valparaíso in Chile and the University of the Basque Country in Spain.
If you wish to attend this seminar online, please send an email to f.a.nobregasantos@uva.nl to receive the zoom-link.